XLS Medical Review 2025: Does It Really Work?


Expert Rating: 3.2/5

Customer Rating: 2.7/5

119 voted

XLS Medical is a weight loss supplement that binds itself to fat to help gets rid of excess weight.

They highlight a clinical study which used the main active ingredient to great success. The fat binding effects are also said to help aid blood sugar levels and overall wellness.

There’s currently no higher rated weight loss supplements than the brands featured in our top 10 list.


XLS Medical Review

Their standard XLS Medical Fat Binder version is made to produce 3 times as many weight loss effects than standard dieting alone. The claim is that it can attach itself to around 27% of total dietary fat, thereby reducing total calorie absorption. A 180 tablet packet is sold on Amazon for $74.97, though this can vary depending on the specific version.

Each packet lasts 30 days when taken at the maximum strength, and it amounts to a daily cost of $2.49. There’s no better affordable and effective weight loss supplements than the brands in our top 10 list.

To use it properly they advise starting at just a month, and not losing more than 2 pounds weekly. A weight loss program is also offered for free support in order to target results over a 12 week period.

The main active ingredient includes:

Litramine: The patented version of the Opuntia ficus-indica cactus. This prickly pear cactus is a rich fiber source which can decrease appetite and reduce the absorption of fat. It’s most historically known as a food source.

This cactus is most often used for its antioxidants which can improve overall health.

Pros:

  • The sole active ingredient is supported by clinical studies.

Cons:

  • An alarming amount of customers failed to see any benefits. This is limited to mainly fat absorption for weight loss.

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There is a clinical study performed on this ingredient which had 200 users take part. This was randomized and double-blind, which is a gold standard for reviews. This took place in 2017 and evaluated users for a yearlong period.

This study was paid for by the pharmaceutical company called InQpharm, and therefore may be potential biased.

An additional claim is that this ingredient can help regulate blood sugar levels, and reduce the craving for sugary foods. It’s unclear how this interest in sugary foods was tested, as we can’t find any science to back up this claim.

Vitamin D3: A form of the essential fat soluble vitamin which affects the absorption of other nutrients, as well as general mood and health.


Fat Binding

The only intended benefit of this brand is to reduce some of the calories which are sourced from fats. This has no effect on metabolism, brain function, or any of the other important factors that result in weight loss. To properly use this it’s recommend to drink a suitable enough amount of water, as it greatly increase fiber intake.

Worse yet, the main study which is used to support the active ingredient are only shown to be effective for a maximum of 37% of fat loss. This will not reduce any calories found in carbohydrates or protein.

When dealing with any fat absorber you have to be cautious of the problematic digestive issues which may make it hard to take over time. The company does make it clear that it is:

“gentle on the system”

But according to some customers, this wasn’t always the case.

When using any fat binder it’s also important to watch out for the loss of fat soluble vitamins, Naturally ingredients like this can reduce nutrient absorption, and some may require the additional support of a multivitamin to make up for the potential loss.

For more active weight loss potential we discovered that the following 10 offered the greatest results.


Business

Perrigo Company plc. Controls this brand and they operate out of both Ireland and the US. The company makes many kinds of pharmaceuticals.

They do not offer a money back guarantee on the official website, which is due to their 3rd party sales. Any possible returns would have to be scheduled with the 3rd party group, though they may not offer a guarantee. This is common to supplement companies that do not sell their own brands, but it’s a major oversight which may lead to people losing money if it doesn’t work.

They also produce many versions of XLS Medical, some of which come in sachets, and versions which are intended for maximum benefits.

To ensure that the supplement will be likely safe, the website states that they uphold:

“international standards”

  • Appetite Suppression:   3.9/5
  • Ingredients Quality:   2.7/5
  • Return Policy:   3.6/5
  • Customer Rating:   2.9/5
  • Value for Money ($74.97*):   3.9/5
  • Overall Rating:   3.2/5

Consumer Opinions

Overwhelmingly the consensus was larger negative. The main problem consumers had was that it simply failed to offer results. There’s currently more negative opinion on their Amazon page than positive feedback. Another criticism other than it simply not working was that it’s hard to take the maximum 6 pills a day, which is a lot to swallow.

There were many who experienced not a single change with a full 30 day supply. Because of this, a criticized it since the advertising makes it seem like it has a likely effective formula.

Rare but noteworthy side effects were also experienced including weight gain and uncomfortable sensations. It’s unknown if this is a common problem since reviews on this brand are mostly centered on the lack of effects.

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Conclusion:

XLS Medical is no doubt unique and made with an ingredient that is supported by some clinical evidence.

The unfortunate reality experienced by many was that it simply did not produce results of any kind, including most importantly, weight loss. There is also a limited intended result from this, as it’s only targeted to get rid of some fats which offer calories, though it’s not for any other possible weight loss benefits.

Much better options are available at a reduced price with better ingredients.